|
KMID : 0861020220370040017
|
|
Korea Journal of Herbology
2022 Volume.37 No. 4 p.17 ~ p.29
|
|
|
The comparative study on the anti-obesity effect of Arctium lappa L. roots with and without microwave processing
|
|
Seo Seong-Wook
Kim Min-Ju
Kim Kyoung
Chung Dong-Min
Shin Mi-Rae
|
|
|
Abstract
|
|
|
Objective : The present study comparatively analyzed the anti-obesity effect of Arctium lappa L. roots with and without microwave processing.
Methods : Four HFD groups except for the Normal group (n=8) were allocated: Control, microwave-processed dried Arctium lappa L. roots (MAL) extract 400 mg/kg/d (MAL400), MAL extract 800 mg/kg/d (MAL800), and the dried Arctium lappa L. roots (DAL) extract 800 mg/kg/d (DAL800). The efficacy of MAL and DAL was confirmed in terms of the serum biochemical index, protein expressions related to the synthesis of triglyceride (TG) and total cholesterol (TC) and β-oxidation, and histopathological staining.
Results : Both MAL and DAL treatments significantly reduced final body weight and body weight gain. MAL800 treatment significantly reduced serum TG, TC, low-density lipoprotein cholesterol, and leptin levels, but the serum high-density lipoprotein cholesterol and adiponectin concentrations were dramatically increased. In particular, leptin in the MAL800 group was reduced by 14.1% compared with the DAL800 group. Moreover, the MAL800 treatment showed an effect superior to the DAL800 treatment in the reduction of serum TC, the sirtuin 1 (Sirt1) activation, and the inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR) gene expression. In particular, unlike the DAL800 treatment, MAL treatment significantly led to the activation of peroxisome proliferator-activated receptor alpha (PPARα). Subsequently, PPARα meaningfully regulated downstream proteins associated with β-oxidation.
Conclusion : These findings suggest that Arctium lappa L. roots with microwave processing effectively ameliorate obesity through the regulation of leptin and TC and the promotion of β-oxidation compared with Arctium lappa L.
roots without microwave processing.
|
|
|
KEYWORD
|
|
|
Arctium lappa L. roots, microwave processing, high-fat diet, leptin, total cholesterol, anti-obesity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|